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A GUI is just a viewer with triggers. If you link the triggers to the correct functions or methods, what you ask should be achievable. For myself have built a few GUI apps to make the user experience better. In those apps, I just use PSSE as a solver (not running the PSSE GUI and then initiate the GUI app from inside).

It is actually not difficult since GUI based programming is not a difficult thing. Python programming with PSSE in principle is the same as other Python programming. You just need to read the API doct and figure out how to make sense with PSSE.

By the way, I do not understand what you mean by "gui clone in WxPython". The kinda standard way to work with WxPython is to use a GUI builder (e.g., WxForm Builder) to design the GUI; then generate the Python code as a module. Create the main app script; import the said module; inherit the GUI class from the said module; adapt it; loop the app. That's basically it.